Speaker #1: Mark A. Frye, M.D.
Mark A. Frye, M.D., is a Consultant in the Department of Psychiatry & Psychology at Mayo Clinic. He is the past Chair of the Department of Psychiatry & Psychology (2010-2020) and is recognized with the distinction of the Stephen and Shelley Jackson Family Professorship in Individualized Medicine.
Born and raised in Rochester, Dr. Frye received his M.D. from the University of Minnesota and completed his psychiatric training at the Semel Institute for Neuroscience and Human Behavior at the David Geffen School of Medicine at UCLA. He subsequently completed a fellowship at the National Institute of Mental Health in Bethesda, Maryland with a research focus on the neurobiology of treatment resistant depression and bipolar disorder.
Dr. Frye and his team established the Mayo Clinic Individualized Medicine Biobank for Bipolar Disorder to identify the underpinning mechanisms of bipolar disorder through genomic studies. An active clinical investigator, he has received research support from NIMH, NIAAA, Mayo Foundation, Brain & Behavior Research Foundation, and industry partners, and has published more than 460 peer-reviewed papers.
He has received numerous awards including the American College of Psychiatry Mood Disorders Research Award (2018), Gerald Klerman Senior and Young Investigator Awards from the Depression Bipolar Alliance (2014, 2003), the International Society for Bipolar Disorder Robert Post MD Mentoring Award (2022) and Mogens Schou Education Award (2011), 2 Mayo Clinic Rome Mentorship Awards (2011, 2012), and 3 UCLA departmental medical student and resident teaching awards (1994, 2003, 2005).
Dr. Frye is a Scientific Chair for Breakthrough Discoveries for thriving with Bipolar Disorder (BD2), a research foundation committed to building a large-scale longitudinal cohort embedded within a learning health network to facilitate new knowledge that rapidly drives improvement in clinical care. He is also the President of the National Network of Depression Centers (NNDC), a network collaborating in clinical innovation, research, and education and Scientific Advisory Board Chair of the Depression Bipolar Support Alliance (DBSA), a leading national organization mission driven to improve the lives of people who live with mood disorders.
Learning Objectives
Upon conclusion of this activity, participants should be able to:
Recognize the neurobiological impact of mania on subsequent clinical decisions for depression care
Identify care gaps and health disparities in bipolar disorder
Formulate roadmap forward to precision diagnostics, novel therapeutics, and individualized care
ATTENDANCE / CREDIT
Text the session code (provided only at the session) to 507-200-3010 within 48 hours of the live presentation to record attendance. All learners are encouraged to text attendance regardless of credit needs. This number is only used for receiving text messages related to tracking attendance. Additional tasks to obtain credit may be required based on the specific activity requirements and will be announced accordingly. Swiping your badge will not provide credit; that process is only applicable to meet GME requirements for Residents & Fellows.
TRANSCRIPT
Any credit or attendance awarded from this session will appear on your Transcript.
For disclosure information regarding Mayo Clinic School of Continuous Professional Development accreditation review committee member(s) and staff, please go here to review disclosures.

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