Upon completion of this activity, participants should be able to:

• Recognize acute “must not miss” neurologic emergencies.
• Implement the data supporting the use of IV thrombolysis for the treatment of acute ischemic stroke.
• Describe the clinical evidence, patient selection, and treatment considerations for the use of endovascular therapy in patients with acute ischemic stroke.
• Diagnose and manage seizure disorders and other neurological spells.
• Identify key aspects of diagnosis and management of acute neurologic complications in primary central nervous system malignancies.
• Describe common complications from cancer immunotherapy, including immune checkpoint inhibitors and chimeric antigen receptor T-cell therapy, as well as their workup and management.
• Identify autoimmune encephalitis and exclude its mimics.
• Describe the central nervous system demyelinating disorders that may require care in the hospital, their differential diagnosis, their workup, and their management.
• Recognize critical warning signs in CNS infection presentations that require urgent management.

Attendance at any Mayo Clinic course does not indicate or guarantee competence or proficiency in the skills, knowledge or performance of any care or procedure(s) which may be discussed or taught in this course.