Summary: 

The syndrome of inappropriate antidiuresis (SIAD) is a major cause of hypotonic hyponatremia. Despite its prevalence, treatment options are sparse, and data on their effect on hyponatremia-associated morbidity such as neurocognitive impairment are largely lacking. New treatment options are needed. The sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin promotes osmotic diuresis via urinary glucose excretion and could be used as a treatment for chronic SIAD. This randomized, double-blind, placebo-controlled, crossover trial with 14 participants revealed that empagliflozin is well tolerated and effective compared with placebo. In addition, treatment with empagliflozin possibly led to an improvement in neurocognitive function. The results set the stage for further studies evaluating empagliflozin as a treatment option in patients with SIAD-induced hyponatremia.

Objectives:

At the conclusion of this activity, the learner should be able to:

• Identify characteristics of SIADH
• Recognize current role and recommendations of SIADH
• Recognize use SGL2 inhibitors and mechanism of action
• Analyze utility of SGL2 inhibitors on chronic SIADH

Bio: Michael Bernaba is a nephrology fellow at Mayo clinic Arizona

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TRANSCRIPT
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