Title: RST DLMP Grand Rounds - Real-Time Quaking-Induced Conversion Assays at Mayo Clinic: From Prion Disease to Emerging Neurodegenerative Diagnostics - September 3, 2025 

Presenter: John R. Mills, Ph.D.

LEARNING OBJECTIVES
Upon completion of this activity, participants should be able to:

• Differentiate the major etiologies of rapidly progressive dementia, including prion diseases and prion-like proteinopathies.
• Evaluate the diagnostic role and performance characteristics of Real-Time Quaking-Induced Conversion (RT-QuIC) compared to traditional CSF and imaging biomarkers in suspected prion disease.
• Appraise the broader applications of RT-QuIC and related seeding assays for neurodegenerative disorders beyond prion disease.

ATTENDANCE / CREDIT
Text the session code (provided only at the session) to 507-200-3010 within 48 hours of the live presentation to record attendance. All learners are encouraged to text attendance regardless of credit needs. This number is only used for receiving text messages related to tracking attendance. Additional tasks to obtain credit may be required based on the specific activity requirements and will be announced accordingly. Swiping your badge will not provide credit; that process is only applicable to meet GME requirements for Residents & Fellows.

TRANSCRIPT
Any credit or attendance awarded from this session will appear on your Transcript.

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