Speaker #1: W. Brad Ruzicka, MD, PhD

Title: Single-cell multi-cohort transcriptomic dissection of bipolar disorder

Speaker statement: 

Dr. Brad Ruzicka earned his MD and PhD degrees from the University of Illinois Medical Scientist Training Program, and he has maintained a focus on postmortem human brain tissue studies throughout his career. Brad performed his thesis work with Drs. Alessandro Guidotti and Erminio Costa in one of the earliest groups to investigate epigenetic mechanisms in the pathology of psychiatric disorders, where he studied overactivity of the DNA methylation machinery in schizophrenia. After graduate school Brad moved to Boston for his clinical training within the MGH/McLean Adult Psychiatry Residency. During residency he performed his postdoctoral work at McLean in the lab of Dr. Francine Benes, investigating the role of DNA methylation in psychotic disorder associated gene expression changes in the human hippocampus. After finishing his training Brad has continued clinical work and research at McLean Hospital, where he is now the director of the Laboratory for Epigenomics in Human Psychopathology, Associate Medical Director of the Harvard Brain Tissue Resource Center, a board-certified psychiatrist working in multiple settings within McLean’s Psychotic Disorders Division, and Assistant Professor of Psychiatry at Harvard Medical School.

Upon completion of this activity, participants should be able to… 

1. Describe the strengths of single-cell RNA sequencing in comparison to bulk tissue assays. 

2. Interpret the relationship between single-cell gene expression changes and bipolar disorder genetics and disease pathophysiology. 

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TRANSCRIPT
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