Game Changing Approach of Delirium:
Development of a point-of-care EEG device, epigenetics biomarker, and mouse model for detection, prediction and novel therapeutics

Gen Shinozaki, MD, Ph.D.

Gen Shinozaki, MD, Ph.D. Graduated from the University of Tokyo, majoring in physics, followed by master's in quantum optics, went on to medical school at the University of Yamanashi. Soon after internship at the United States Naval Hospital in Okinawa, he joined Mayo for Psychiatry Residency, followed by CL fellowship, under the directorship by Dr Kemuel Philbrick and Dr Jim Rundell.

It was the time when he was mentored by the former chair, Dr David Mrazek at the start of his research career.

He received both Howard Rome Grand Round Award and Writing Award upon graduation.

After 4 years at Sioux Falls VA Hospital for his J-1 visa waiver job, he moved to the University of Iowa, where he was mentored by the chair, Dr Jimmy Potash, who now the chair at the Johns Hopkins.

During his time at Iowa, he was awarded by many extramural funding including NIMH K23 (2015), NSF I-Corp (2017), and NIHM R01 (2020). The University of Iowa (UI) Roy J. and Lucille A. Carver College of Medicine also chose me as the HelenJohnson Scholar for Informatics in 2014.

He was selected as the recipient of the 2018 Dlin/Fischer Clinical Research Award and 2019 Visiting Professor Award from the Academy of Consultation-Liaison Psychiatry for my research work in the development of a bispectral EEG (BSEEG) device and algorithm to detect delirium and predict patient outcomes. 

Over 50 peer reviewed publications, ranging from device development, epigenetics biomarker, and mouse model and more.

Mentored over 70 trainees, many of them went on to medical school, graduate school, and psychiatry residency, faculty jobs, building new generation of talented individuals.

Learning Objectives:

Upon conclusion of this activity, participants should be able to:

•             Demonstrate that a novel bispectral EEG (BSEEG) device can detect delirium and predict patient outcomes including mortality.

•             Recognize that epigenetic mechanisms, especially DNA methylation, is playing a potential role in pathophysiology of delirium, and DNA methylation signals can be used as reliable biomarker of delirium.

•             Conclude that a mouse model of delirium using BSEEG method can be used to discover novel therapeutics of delirium.

1.00 AMA PRA Category 1 Credit(s)™ hour is offered for watching this presentation via Zoom.  Ethos will be implemented for all post presentation surveys.  To document your attendance, please text the code given at the presentation to 507-200-3010.  For questions, email rstpsychgr@mayo.edu

Accreditation Statement
In support of improving patient care, Mayo Clinic College of Medicine and Science is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Credit Statement(s):

AMA
Mayo Clinic College of Medicine and Science designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

APA
Continuing Education (CE) credits for psychologists are provided through the co-sponsorship of the American Psychological Association (APA) Office of Continuing Education in Psychology (CEP). The APA CEP Office maintains responsibly for the content of the programs.
 

This activity is approved for a maximum of 1.00 credits. Credit is awarded only for actual instructional time.
 

ASWB
As a jointly Accredited Organization, Mayo Clinic College of Medicine and Science is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program.  Organizations, not individual courses, are approved under this program.  State and provincial regulatory boards have the final authority to determine whether an individual course may be accepted for continuing education credit.  Mayo Clinic College of Medicine and Science maintains responsibility for this course.  Social workers completing this course will receive 1.00 continuing education credits. 

Archived webcast available at: Psychiatry & Psychology Video Library

Disclosure Summary

As a provider accredited by Joint Accreditation for Interprofessional Continuing Education, Mayo Clinic College of Medicine and Science must ensure balance, independence, objectivity and scientific rigor in its educational activities.  All who are in a position to control the content are required to disclose all financial relationships with any ineligible company.   Faculty will also identify any off-label and/or investigational use of pharmaceuticals or instruments discussed in their content for FDA compliance

Listed below are individuals with control of the content of this program who have disclosed…

Relevant financial relationship(s) with ineligible companies:
None

No relevant financial relationship(s) with ineligible companies:
Chad Ellis, LICSW, Aimee Karstens, PhD, MA, Sydney Kelpin, PhD, Bhanu Kolla, MD, Wendy Moore, MSN, RN, NE-BC, Charlene Nelson (coordinator), Amber Pearson (coordinator), Amber Ruth (coordinator), Tyler Mielke (coordinator), Michelle Skime, MS

Speaker: Gen Shinozaki, MD, Ph.D

For disclosure information regarding Mayo Clinic School of Continuous Professional Development accreditation review committee member(s), please go here. 

ATTENDANCE/CREDIT
Text the session code (provided only at the session) to 507-200-3010 within 48 hours of the live presentation to record attendance.  All learners are encouraged to text attendance regardless of credit needs.  This number is only used for receiving text messages related to tracking attendance.  Additional tasks to obtain credit may be required based on the specific activity requirements and will be announced accordingly. Swiping your badge will not provide credit; that process is only applicable to meet GME requirements for Residents & Fellows. 

TRANSCRIPT
Any credit or attendance awarded from this series will appear on your Transcript.

DEPARTMENT WEBSITE
Visit the department's website for additional information.

COURSE DIRECTOR(S)
Bhanu Prakash Kolla, MD

QUESTIONS?  
Contact Amber Ruth at ph. 5-1791 or Amber Pearson at ph. 4-5916.