Summary:  Calciphylaxis is a rare and life-threatening syndrome of vascular calcification.  It leads to painful and pruritic skin lesions, and generally has a poor prognosis.  Calciphylaxis typically affects patients with end-stage renal disease. In this study, 19 cases (hemodialysis with calciphylaxis) were matched with 54 (hemodialysis without calciphylaxis). Conditional logistic regression was used to identify a risk factors for calciphylaxis.  Identified risk factors for calciphylaxis included:  higher serum alkaline phosphatase levels, higher serum phosphate levels is, female gender, and lower serum albumin.  Based on these observations, dietary phosphate restriction may be important as well as maintaining adequate nutrition.  Perspective controlled multi center trials should be done to better understand risk factors associated with calciphylaxis.

Objectives: At the conclusion of this activity, the learner should be able to:

• Define calciphylaxis
• Explain calciphylaxis clinical manifestations  
• Explain calciphylaxis epidemiology
• Define calciphylaxis epidemiology
• Describe calciphylaxis treatment strategies
• Identify and recognize risk factors associated with calciphylaxis

Bio: A. Rauf Mazhar, Richard Johnson, et al. “Risk factors and mortality associated with calciphylaxis in end-stage renal disease.” Kidney International, Vol. 60 (2001), pp. 324–332

ATTENDANCE / CREDIT
Text the session code (provided only at the session) to 507-200-3010 within 48 hours of the live presentation to record attendance. All learners are encouraged to text attendance regardless of credit needs. This number is only used for receiving text messages related to tracking attendance. Additional tasks to obtain credit may be required based on the specific activity requirements and will be announced accordingly. Swiping your badge will not provide credit; that process is only applicable to meet GME requirements for Residents & Fellows.

TRANSCRIPT
Any credit or attendance awarded from this session will appear on your Transcript.

For disclosure information regarding Mayo Clinic School of Continuous Professional Development accreditation review committee member(s) and staff, please go here to review disclosures.