Extracellular Matrix Across Psychiatric Disorders
Harry Pantazopoulos, PhD

Harry Pantazopoulos’ research studies are focused on identifying the neuropathological correlates of psychiatric disorders with an emphasis on the role of the extracellular matrix and circadian rhythms. Together with his collaborators and lab members, he pursues these questions using a combination of human postmortem and animal model approaches. The long-term research goal of the Pantazopoulos lab is to develop a foundation of changes in neurocircuitry in several diseases including Schizophrenia, Bipolar Disorder, Major Depression, Autism and Substance Use Disorders, that we can leverage to develop more effective treatments. In addition, the Pantazopoulos lab’s research aims to identify basic biological mechanisms that will provide insight into how the circadian system and the extracellular matrix regulate neural functions and behavior.

Dr. Pantazopoulos began his laboratory training on human postmortem brain studies in 1998 in the Harvard Brain Tissue Resource Center and in the laboratory of Dr. Francine M Benes at Mclean Hospital, Harvard Medical School. He continued this training by incorporating both animal model and human postmortem brain studies with Dr. Sabina Berretta at Mclean Hospital, Harvard Medical School. Dr. Pantazopoulos obtained his PhD in circadian neurobiology with Dr. Fred Davis at Northeastern University in 2011 and continued his studies on the extracellular matrix and circadian rhythms in psychiatric disorders as a junior faculty member with Dr. Berretta at Mclean Hospital. Dr. Pantazopoulos then joined the University of Mississippi Medical Center in 2019 as an Assistant Professor to continue and expand on his research into the roles of the extracellular matrix and circadian system in psychiatric disorders.

His  research is currently funded by NIMH, the Baszucki Brain Research Foundation, the Inflammation Healing Foundation, and the Department of Defense.  Dr. Pantazopoulos serves as an ad-hoc reviewer for twelve journals, including Neuropsychopharmacology, PNAS and Molecular Psychiatry, and as a guest editor for two volumes of a special issue in Frontiers in neuroscience on extracellular matrix molecules in adult brain functions and disease states, and in Neural Plasticity for a Special Issue on circadian rhythms in health and disease.

Dr. Pantazopoulos also regularly trains undergraduate, graduate, and medical students in addition to formal lectures in the graduate program in neuroscience and serves as a medical student advisor for first- and second-year medical students.

Learning Objectives
Upon conclusion of this activity, participants should be able to:

• Summarize the function of Perineuronal Nets and Extracellular Matrix Molecules in Developmental and Adult Brain Processes.
• Specify how extracellular matrix molecules are altered between psychiatric disorders.

1.00 AMA PRA Category 1 Credit(s)™ hour is offered for watching this presentation via Zoom.  Ethos will be implemented for all post presentation surveys.  To document your attendance, please text the code given at the presentation to 507-200-3010.  For questions, email rstpsychgr@mayo.edu

Accreditation Statement
In support of improving patient care, Mayo Clinic College of Medicine and Science is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Credit Statement(s):

AMA
Mayo Clinic College of Medicine and Science designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credits^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

APA
Continuing Education (CE) credits for psychologists are provided through the co-sponsorship of the American Psychological Association (APA) Office of Continuing Education in Psychology (CEP). The APA CEP Office maintains responsibly for the content of the programs.
 

This activity is approved for a maximum of 1.00 credits. Credit is awarded only for actual instructional time.
 

ASWB
As a jointly Accredited Organization, Mayo Clinic College of Medicine and Science is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program.  Organizations, not individual courses, are approved under this program.  State and provincial regulatory boards have the final authority to determine whether an individual course may be accepted for continuing education credit.  Mayo Clinic College of Medicine and Science maintains responsibility for this course.  Social workers completing this course will receive 1.00 continuing education credits. 

Archived webcast available at: Psychiatry & Psychology Video Library

Disclosure Summary
As a provider accredited by Joint Accreditation Interprofessional Continuing Education, Mayo Clinic College of Medicine and Science (Mayo Clinic School of CPD) must ensure balance, independence, objectivity and scientific rigor in its educational activities. Course Director(s), Planning Committee Members, Faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity.  Safeguards against commercial bias have been put in place.  Faculty also will disclose any off label and/or investigational use of pharmaceuticals or instruments discussed in their presentation.  Disclosure of these relevant financial relationships will be published in activity materials so those participants in the activity may formulate their own judgments regarding the presentation.

Listed below are individuals with control of the content of this program who have disclosed…

Relevant financial relationship(s) with industry:
None

No relevant financial relationship(s) with industry:
Chad Ellis, LICSW, Aimee Karstens, PhD, MA, Sydney Kelpin, PhD, Bhanu Kolla, MD, Wendy Moore, MSN, RN, NE-BC, Charlene Nelson (coordinator), Amber Pearson (coordinator), Michelle Skime, MS

Speakers: Harry Pantazopoulos, PhD

For disclosure information regarding Mayo Clinic School of Continuous Professional Development accreditation review committee member(s), please go here. 

ATTENDANCE/CREDIT
Text the session code (provided only at the session) to 507-200-3010 within 48 hours of the live presentation to record attendance.  All learners are encouraged to text attendance regardless of credit needs.  This number is only used for receiving text messages related to tracking attendance.  Additional tasks to obtain credit may be required based on the specific activity requirements and will be announced accordingly. Swiping your badge will not provide credit; that process is only applicable to meet GME requirements for Residents & Fellows. 

TRANSCRIPT
Any credit or attendance awarded from this series will appear on your Transcript.

DEPARTMENT WEBSITE
Visit the department's website for additional information.

COURSE DIRECTOR(S)
Bhanu Prakash Kolla, MD

QUESTIONS?  
Contact Charlene Nelson at ph. 5-5428 or Amber Pearson at ph. 4-5916.