PRESENTATION TITLE

Clonal Hematopoiesis - Translating Bench to Bedside

PRESENTER(S)

Mrinal S. Patnaik, M.B.B.S., M.D., Assistant Professor of Oncology, College of Medicine, Associate Professor of Medicine, Consultant - Division of Hematology, Chair, Acute Leukemia and Chronic Myeloid Neoplasms Disease-Oriented group, Director, Center for Individualized Medicine Epigenomics program, Mayo Clinic, Rochester, Minnesota

PRESENTER BIO

Mrinal Patnaik, M.B.B.S., M.D., is a Physician Scientist with the Division of Hematology and an Associate Professor in the Department of Medicine at Mayo Clinic, Rochester, MN, with a specific interest in epigenetic deregulation in age-related clonal hematopoiesis (CH) and ageing-related myeloid neoplasms, specifically Chronic Myelomonocytic Leukemia (CMML). He is Chair of the Acute Leukemia and Chronic Myeloid Neoplasms disease-oriented group and the Director of the Center for Individualized Medicine Epigenomics program. CMML is an aggressive malignancy associated with high morbidity and mortality, and in great need of new treatment options. He has carried out important preclinical and prognostic work in CMML and have importantly demonstrated the prevalence of epigenetic (TET2) and chromatin dysregulation (ASXL1) along with the negative prognostic impact of mutations such as ASXL1. This work has led to the development of the Mayo Molecular Model (Leukemia 2014); a contemporary prognostic model for patients with CMML that now is applied worldwide. In July 2015, he was awarded the NIH CTSA KL-2 scholar award to further his work in CMML and have used this time and mentoring to define the interplay between the genomic and epigenetic landscape of proliferative and dysplastic CMML subtypes (Nature Comm. 2021). In addition, he has used extensive epigenetic techniques to profile ASXL1 mutant and wild type CMML samples (Nature Comm. 2022). He is the principal investigator of the Mayo Clinic CMML biorepository (IRB-15-003786) which has >750 molecularly annotated patient samples and directs a CMML translational lab currently investigating the genetic and epigenetic profile of CMML, with special emphasis on therapeutics.

VIEWING LOCATIONS
Zoom Registration Link

LEARNING OBJECTIVES

• Define the prevalence and biology of Clonal Hematopoiesis.
• Demonstrate the association between CH and Cancer risk.
• Apply CH testing in Hematology and Oncology Clinics

ATTENDANCE / CREDIT
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TRANSCRIPT
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