Session date: 
12/07/2023 - 12:00pm to 1:00pm

PRESENTATION TITLE
Senescence of Alveolar progenitor cells drives progressive Pulmonary Fibrosis  

Learning Objectives
Upon completion of this activity, participants should be able to: 

•Demonstrate that AT2 progenitor cell senescence— as opposed to their direct ablation—induces progressive pulmonary fibrosis.
•Evaluate that the stabilization of p53 by acetylation in AT2 cells promote senescence and differentiation to Krt8high cells that leads to progressive pulmonary fibrosis.
•Access further whether this process is mediated by the depressed expression of Sirt1, a deacetylase of p53.
•Evaluate whether p53 acetylation is a switch that converts homeostatic TGFβ signaling in AT2 cells into a maladaptive signal that drives non-resolving, progressive fibrosis.

 

ATTENDANCE / CREDIT
Text the session code (provided only at the session) to 507-200-3010 within 48 hours of the live presentation to record attendance. All learners are encouraged to text attendance regardless of credit needs. This number is only used for receiving text messages related to tracking attendance. Additional tasks to obtain credit may be required based on the specific activity requirements and will be announced accordingly. Swiping your badge will not provide credit; that process is only applicable to meet GME requirements for Residents & Fellows.

TRANSCRIPT
Any credit or attendance awarded from this session will appear on your Transcript.

For disclosure information regarding Mayo Clinic School of Continuous Professional Development accreditation review committee member(s) and staff, please go here to review disclosures.

Presenter: 
Changfu Yao, Ph.D.
Support location: 
Arizona

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Support location: 
Arizona